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To better assist you with your request, please choose a research area provided by The Institute of Environmental Toxicology. In case you cannot find an exact match, simply select any service, and our concierge team will swiftly address it once your request has been submitted.

Mammalian Toxicology

Use toxicity testing models to carry out required FDA or REACH safety testing.
Dermal Toxicology

Assess toxicity in rodent dermal testing models.
Reproductive Toxicology

Study adverse sexual function and fertility and examine teratogenicity of compounds.
Oral Toxicology

Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Inhalation Toxicology

Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
In Vivo REACH Services

Performing testing when in vitro studies cannot be used to predict biological responses
OECD 471: Bacterial Reverse Mutation Test (Ames)

Measure the mutagenic potential of test compounds.
OECD 487: In Vitro Mammalian Cell Micronucleus Test

Assess whether a test substance induces chromosomal changes in cultured cells.
OECD 489: In Vivo Mammalian Alkaline Comet Assay

Measure the mitogenic and genotoxic potential of test compounds.
OECD 474: Mammalian Erythrocyte Micronucleus Test

The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
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