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Chemistry, Manufacturing and Controls (CMC)

Request Chemistry, Manufacturing and Controls services
Compound Synthesis

Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks

Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Lead Optimization

Perform chemical structural changes to improve preclinical drug candidate.
Impurity Synthesis

Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
HTS Libraries

Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Chiral Separation

Purify therapeutically active isomers of drug candidates.
Stable Isotope Synthesis

Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
CYP Inhibition Assay

Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Cytochrome P450s

Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.