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In Vitro REACH Services
Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
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Cytotoxicity
Test for effects on cell viability and proliferation
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In Vivo REACH Services
Performing testing when in vitro studies cannot be used to predict biological responses
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OECD 471: Bacterial Reverse Mutation Test (Ames)
Measure the mutagenic potential of test compounds.
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OECD 487: In Vitro Mammalian Cell Micronucleus Test
Assess whether a test substance induces chromosomal changes in cultured cells.
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OECD 474: Mammalian Erythrocyte Micronucleus Test
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
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OECD 473: In Vitro Mammalian Chromosomal Aberration Test
Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
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OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay)
Determine if a compound is mutagenic by using cultured mammalian cells.
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OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).