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CYP Inhibition Assay

Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Cytochrome P450s

Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Metabolic Stability

Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes

Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
CYP Induction

Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
Metabolic Stability in Microsomes

Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Phase I Metabolism

Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Metabolite Synthesis

Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Phase II Metabolism

Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Pesticide Product Testing

Use laboratory assays to evaluate the efficacy, safety and selectivity of a pesticide under GLP standards.