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HBS: Human Biological Samples

Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Safety Pharmacology

Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Cell Based Assays

Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cytotoxicity

Test for effects on cell viability and proliferation
Histology

Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Human Primary Cell Isolation

Isolate primary cells from various human tissues.
Metabolic Stability

Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes

Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Human Primary Cells

Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that have not be immortalised and after a certain amount of passaging they will reach senescence. iPSCs, induced pluripotent stem cells, are cells that have (through GM or culturing conditions) have been revert back to the pluripotency state. The original cells can be a cell line or a primary cell.
Hepatocyte Toxicity

Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
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