This core laboratory is an integral part of the NHLBI Research Scientist Program and the Center for Sickle Cell Disease. It contains bench space to accommodate up to eight (8) researchers and has capabilities for advance biochemical, molecular biological and proteomic research. The laboratory contains: a sterility cabinet, a walk-in cold room, a chemical hood and other equipment (including low and high pressure chromatography systems, various centrifuges, plate readers, spectrophotometers, scintillation counter, phosphoimager, speedVac and gel dryer, PCR machines including quantitative PCR, digital cameras and incubators with CO2). It also accommodates a MultiPlex (Bio-Rad) instrument.