Hydroxyurea

DESCRIPTION

Hydroxyurea is a monohydroxyl-substituted urea antimetabolite that exhibits antineoplastic properties by the inhibition of DNA replication and cell proliferation. It inactivates ribonucleotide reductase and induces cell cycle arrest in S-phase. It is reported that hydroxyurea reduces leukocyte adhesion and inhibits the proliferation of human lung cancer cells.

DETAILS

Purity: ≥95%
Synonyms: Hydroxycarbamide, N-Hydroxyurea, Hydrea, Oxyurea
Cas Number: 127-07-1
References: Yarbro, J. W. (1992, June). Mechanism of action of hydroxyurea. In Seminars in oncology (Vol. 19, No. 3 Suppl 9, pp. 1-10). Young, C. W., & Hodas, S. (1964). Hydroxyurea: inhibitory effect on DNA metabolism. Science, 146(3648), 1172-1174. Elford, H. L. (1968). Effect of hydroxyurea on ribonucleotide reductase.
Application: FA
Formulation: Crystalline solid
Chemical Name: hydroxyurea
Molecular Weight: 76.1
Molecular Formula: CH4N2O2
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: C(=O)(N)NO