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T3512

S49076 HCl

TargetMol

- Open Babel Depiction N H O N O O S HO N N H

DESCRIPTION

S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 HCl inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 HCl was established and correlated well with impact on tumor growth.

DETAILS

  • Cas: 1265966-31-1
  • Purity: 98%
  • Smiles: Cl.O=C1CSC(=O)N1Cc1ccc2NC(=O)\C(=C/c3cc(CN4CCOCC4)c[nH]3)c2c1
  • Category: Compound
  • Molecular Weight: 439.85
  • Molecular Formula: C22H18ClN3O5

Lead Time: Please Inquire

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