mouse monoclonal IgG1; PBF Antibody (E-8) is an IgG1 κ mouse monoclonal PBF antibody (also designated PBF antibody) that detects the PBF protein of mouse, rat and human origin by WB, IP, IF and ELISA. PBF Antibody (E-8) is available as both the non-conjugated anti-PBF antibody form, as well as multiple conjugated forms of anti-PBF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. PBF, also known as PTTG1IP (pituitary tumor-transforming 1 interacting protein), is a 180 amino acid single-pass type I membrane protein that localizes to both the cytoplasm and the nucleus and contains a coiled-coil domain. Expressed ubiquitously, PBF interacts with PTTG and is thought to facilitate the nuclear translocation of PTTG, thereby allowing the PTTG-dependent transcriptional activation of fibroblast growth factor (FGF). The gene encoding PBF maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's Disease, amyotrophic lateral sclerosis and, most notably, Down Syndrome (also known as trisomy 21).

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.