KCNAB3 Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 9196
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: KCNAB3
Other Names: Voltage-gated potassium channel subunit beta-3, K(+) channel subunit beta-3, Kv-beta-3, KCNAB3, KCNA3B
Availability: 2 weeks
Bio Background: Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. Four sequence-relatedpotassium channel genes - shaker, shaw, shab, and shal - have beenidentified in Drosophila, and each has been shown to have humanhomolog(s). This gene encodes a member of the potassium channel,voltage-gated, shaker-related subfamily. This member is one of thebeta subunits, which are auxiliary proteins associating withfunctional Kv-alpha subunits. This member and the KCNA5 geneproduct assemble into a heteromultimeric A-type channel thatinactivates completely and is significantly faster than otherA-type Kv channels.
Bio References: Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Leicher, T., et al. J. Biol. Chem. 273(52):35095-35101(1998)McCormack, K., et al. FEBS Lett. 370 (1-2), 32-36 (1995) :
Primary Accession: O43448