Human APP Protein, His Tag (active enzyme, MALS verified)

DESCRIPTION

Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 500ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human APP Protein, His Tag (APP-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Met 687 (Accession # P05067-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: APP
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Leu 18 - Met 687
Swiss-prot: P05067-1
Package Size: 500ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 77.9 kDa. The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 77.9 kDa
Shipping Condition: RT
Species Reactivity: Human
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