Polyclonal Antibody to ABL1/2 (Ab-393/439)

DESCRIPTION

Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. ocalizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that eads to an inhibition of proteasomal activity and cell cycle transition blocks. Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N.N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.

DETAILS

Gene: ABL1
App Id: WB
Antigen: ABL1/2 (Ab-393/439)
Gene Id: 25
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: P00519/P42684
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human,Mouse
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: ABL|| v-abl|| c-ABL|| p150|| JTK7
Application Note: Predicted MW: 135 210kd, Western blotting: 1:500~1:1000
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around aa.391~395/437~441(D-T-Y-T-A) derived from Human ABL1/2.