mouse monoclonal IgG1; CRISP-2 Antibody (D-10) is an IgG1 κ mouse monoclonal CRISP-2 antibody (also designated CRISP-2 antibody) that detects the CRISP-2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CRISP-2 Antibody (D-10) is available as both the non-conjugated anti-CRISP-2 antibody form, as well as multiple conjugated forms of anti-CRISP-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins which may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. CRISP-1 coats the postacrosomal region of sperm heads as they pass through the epididymis. CRISP-1 is found in all regions of the epididymis, ductus deferens, seminal plasma and sperm. CRISP-2, also known as testis-specific protein TPX1 or cancer/testis antigen 36 (CT36), is a 243 amino acid secreted protein. Expressed in the testis and epididymis, CRISP-2 is thought to be involved in calcium fluxes during sperm capacitation by regulating the activity of certain ion channels. CRISP-3 is expressed in pancreas and prostate tissues and, along with CRISP-1, is expressed in saliva. The gene that encodes CRISP-3 is an early response gene that may participate in the pathophysiology of the auto-immune lesions of Sjogren's syndrome.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.