E6489Hu
Human Strumpellin, STRUM ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699).
Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420).
May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).
DETAILS
- GeneID: 6840
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 247,746
- Synonyms: Archvillin;MFM10;p205/p250;STRUM;Supervillin
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: SVIL
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 10.55ng/L
- Target Protein: STRUM
- Detection Range: 20-6000ng/L
- Full Product Name: Strumpellin
- Standard Solution: 6400ng/L
- UniProt Accession: O95425