mouse monoclonal IgG1; CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11) is an IgG1 κ mouse monoclonal CB1 antibody that detects CB1 of mouse, rat and human origin by WB, IP, IF and ELISA. CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11) is available as the non-conjugated anti-CB1 antibody form, as well as multiple conjugated forms of anti-CB1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The cannabinoid receptors (CB1 and CB2) are G-protein coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids. CB1 is expressed in brain tissue and, in low levels, in testis. CB2 has been shown to be expressed only by cells of the immune system, specifically by HL-60 cells. The cannabinoid receptors mediate most of the cannabinoid-induced responses in a dose-dependent, stereoselective manner. Phosphorylation of CB1 on serine 316 leads to a disruption of CB1-mediated inhibition of calcium channels and activation of potassium currents. This response system is thought to be involved in specific brain functions, such as nociception, control of movement, memory, and neuroendocrine regulation as well as having a possible role in brain development. In addition, CB1 may mediate the addictive behavior involved with the use of psychoactive cannabinoids, such as THC in marijuana.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.