RAF1 Antibody (S339) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5894
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RAF1
Other Names: RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1, RAF1, RAF
Availability: 2 weeks
Bio Background: RAF1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, RAF1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Bio References: Chong, H., et al., J. Biol. Chem. 278(38):36269-36276 (2003).Lee, M., et al., Cancer Lett. 193(1):57-64 (2003).Alavi, A., et al., Science 301(5629):94-96 (2003).Fringer, J., et al., J. Biol. Chem. 278(23):20612-20617 (2003).Oehrl, W., et al., J. Biol. Chem. 278(20):17819-17826 (2003).
Primary Accession: P04049
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7816k was selected from the S339 region of human RAF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.