Anti-CD103 / Integrin 'E'7 (T-Cell Lymphoma & Hairy Cell Leukemia Marker) Monoclonal Antibody(Clone: ITGAE/2063)

DESCRIPTION

This MAb recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E beta-7 (aEb7) integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Antibody to CD103 is an extremely useful addition to the IHC panel for the diagnosis of hairy cell leukemia (HCL).

DETAILS

Gene: ITGAE
App Id: IHC
Gene Id: 3682
Isotype: Mouse IgG2c, kappa
Clone Name: ITGAE/2063
Uniprot Id: P38570
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human
Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: CD103; Human mucosal lymphocyte antigen 1 (HML1 antigen); Integrin alpha E heavy chain; Integrin alpha E light chain; Integrin alpha E, epithelial-associated; Integrin alpha E1; Integrin alpha-IEL (intestinal intraepithelial lymphocytes); Integrin alpha M290; Integrin alpha-E heavy chain.
Application Note: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinant human ITGAE protein fragment (exact sequence is proprietary)