Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free

DESCRIPTION

Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

DETAILS

Tag: C-10×His | Native
Host: CHO
Size: 1mg
Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
Format: Powder
Purity: 95%
Source: Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H53W3) is expressed from CHO cells. It contains AA Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2) (Accession # P20701-1 (ITGAL) & P05107-1 (ITGB2)).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Integrin alpha L beta 2
Accession: NM_002209.1 | NP_000202.3
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2)
Swiss-prot: P20701-1 (ITGAL) & P05107-1 (ITGB2)
Package Size: 500ug*2
Characteristics: Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAL and ITGB2, has a calculated MW of 124.1 kDa (ITGAL) & 80.2 kDa (ITGB2). Subunit ITGAL is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 140-150 kDa (ITGAL) and 90-95 kDa (ITGB2) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 124.1 kDa | 80.2 kDa
Shipping Condition: RT
Species Reactivity: Human
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