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IWP-2 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.


  • Purity: ≥95%
  • Synonyms: CHEMBL1257064, F0579-0037
  • Cas Number: 686770-61-6
  • References: Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Loh, Y. N., Hedditch, E. L., Baker, L. A., Jary, E., Ward, R. L., & Ford, C. E. (2013). The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC cancer, 13(1), 174. Mo, M. L., Li, M. R., Chen, Z., Liu, X. W., Sheng, Q., & Zhou, H. M. (2013). Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncology letters,5(5), 1719-1723.
  • Application: FA
  • Formulation: Crystalline solid
  • Chemical Name: N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
  • Molecular Weight: 466.6
  • Molecular Formula: C22H18N4O2S3
  • Storage Conditions: Product should be kept at -20°C.
  • Pubchem Openeye Can Smiles: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4