Phospho-Ship2 (Tyr1135) (Clone: 1D2) rabbit mAb

DESCRIPTION

Ship2 (SH2-containing inositol phosphatase 2, phospho Ship2) is a homolog of Ship1. Ship2 is highly expressed in the heart, in skeletal muscle, and in the placenta (1). SHIP2 negatively regulates insulin signaling (2), and Ship2 polymorphisms have been linked to hyperglycemia (3). Phospho Ship2 has been identified as a potential therapeutic target for the treatment of obesity and type 2 diabetes (4,5). The Ship2 residue Tyr1135 is phosphorylated in human cancer cells (6-8).

DETAILS

App Id: FACS
Isotype: Rabbit IgG1k
Format Id: Purified
Clone Name: Ship2Y1135-1D2
Host Animal: Rabbit
Clonality Id: Monoclonal
Conjugate Id: Unconjugated
Reactivity Id: Human, Mouse
Product Content: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Alternative Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Inositol polyphosphate phosphatase-like protein 1, INPPL-1, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2
Application Note: 1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml)
Storage Condition: Store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A synthetic phospho-peptide corresponding to residues surrounding Tyr1135 of human phospho Ship2