Torcetrapib

DESCRIPTION

A CETP inhibitor (IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively); selective for CETP over PLTP, LCAT, and hepatic and lipoprotein lipases at 10 µM; inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1 at 30 mg/kg; increases mean arterial blood pressure in Zucker fa/fa diabetic rats at 60 and 200 mg/kg

DETAILS

Inchi: InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
Smiles: O=C(OC)N(CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@H]2C[C@@H](CC)N(C(OCC)=O)C3=CC=C(C(F)(F)F)C=C32
Inchikey: CMSGWTNRGKRWGS-NQIIRXRSSA-N
Cas Number: 262352-17-0
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C26H25F9N2O4
Formula Weight: 600.5
Shelf Life Days: 1460