Anti-CD56 / NCAM Monoclonal Antibody (Clone:MEM-188)

DESCRIPTION

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.

DETAILS

Gene: NCAM1
App Id: FACS, IP, IHC
Antigen: CD56
Gene Id: 4684
Isotype: Mouse IgG2a
Format Id: Purified
Clone Name: MEM-188
Uniprot Id: P13591
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Purified by protein-A affinity chromatography
Reactivity Id: Human, Non-Human Primates
Alternative Name: NCAM1||NCAM
Application Note: Flow Cytometry Recommended dilution:3 µg/ml Immunoprecipitation Immunohistochemistry Recommended dilution: 1:50 Pretreatment: Heat retrieval (microwave oven) in citrate buffer, standard ABC visualization. Positive tissue: Positive membrane-specific reaction in adjacent peripheral nerve Staining of paraprostatic autonomic ganglion. Staining technique: Standard ABC technique (DAB+).
Storage Condition: Store at 2-8°C. Do not freeze.
Immunogen Information: KG-1 human acute myelogenous leukemia cell line