mouse monoclonal IgG1; PGM 1 Antibody (D-8) is an IgG1 κ mouse monoclonal PGM 1 antibody (also designated PGM 1 antibody) that detects the PGM 1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. PGM 1 Antibody (D-8) is available as both the non-conjugated anti-PGM 1 antibody form, as well as multiple conjugated forms of anti-PGM 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphoglucomutase, which belongs to the phophohexose mutase family, plays a role in glycogen catabolism (glycogenolysis) as well as in the process of glycogen synthesis (glycogenesis). During glycogenolysis, PGM converts glucose-1-phosphate to glucose-6-phosphate, thus promoting glycolysis and the pentose phosphate pathway. During glycogenesis, PGM functions in the opposite manner, converting glucose-6-phosphate into glucose-1-phosphate, to facilitate glycogen synthesis. PGM has three structural loci: PGM1, PGM2 and PGM3. These three genetic forms of PGM differ in amino acid sequences but catalyze the same reactions, therefore indicating that they are isozymes. PGM1, a 562 amino acid protein, is highly polymorphic; three mutations and four intragenic recombination events between the three mutation sites generate eight protein variants. All phosphoglucomutases act as monomers and bind one magnesium ion per subunit.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.