30-2428
PerCP Conjugated, Anti-CD31 / PECAM-1 Monoclonal Antibody (Clone:MEM-05)
Abeomics
DESCRIPTION
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
DETAILS
- Gene: PECAM1
- App Id: FACS
- Antigen: CD31
- Gene Id: 5175
- Isotype: Mouse IgG1
- Clone Name: MEM-05
- Uniprot Id: P16284
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Reactivity Id: Human
- Alternative Name: PECAM1
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: Leukocytes of patient suffering from LGL-type leukaemia