5855822-500mg 5855822-50mg
Puromycin dihydrochloride
Biogems
DESCRIPTION
Puromycin is an aminonucleoside antibiotic and protein synthesis inhibitor. It is a reversible inhibitor of dipeptidyl-pepdidase II (serine peptidase) and cytosol alanyl aminopeptidase. Puromycin functions by inhibiting translation and it also inhibits the transportation of protein into the mitochondria.
DETAILS
- Purity: ≥98%
- Synonyms: Puromycin HCl, Stylomycin hydrochloride, CL13900, P-638
- Cas Number: 58-58-2
- References: Traut, R. R., & Monro, R. E. (1964). The puromycin reaction and its relation to protein synthesis. Journal of molecular biology, 10(1), 63-72. Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., & Yamanaka, S. (2008). Generation of mouse induced pluripotent stem cells without viral vectors.Science, 322(5903), 949-953. Vara, J. A., Portela, A., Ortìn, J., & Jimenez, A. (1986). Expression in mammalian cells of a gene from Streptomyces alboniger conferring puromycin resistance. Nucleic acids research, 14(11), 4617-4624.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
- Molecular Weight: 544.4
- Molecular Formula: C22H29N7O5 2HCl
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl