mouse monoclonal IgG2b; p-β-catenin Antibody (BC-22) is an IgG2b κ mouse monoclonal p-beta-catenin antibody (also designated beta-Catenin or CTNNB1 antibody) that detects the p-beta-catenin protein of mouse, rat and human origin by WB, IP and IF. p-β-catenin Antibody (BC-22) is available as the non-conjugated anti-p-beta-catenin antibody. The catenins, α, β and γ, are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play critical roles in mediating cellular adhesion. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin also forms complexes with the tumor suppressor protein APC. Amino acid alterations at residues around Ser 33, one of the targets for phosphorylation of glycogen synthase kinase-3β, result in accumulation of the β-catenin protein in the cytoplasm and nucleus. Pin1 is a novel regulator of β-catenin signaling that directly binds a phosphorylated Ser-Pro motif next to the APC-binding site in β-catenin, inhibiting the interaction with APC and increasing β-catenin translocation into the nucleus. Thus, Pin1 overexpression may contribute to the upregulation of β-catenin in tumors such as breast cancer.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.