3316280-50mg 3316280-10mg
IQ-1
Biogems
DESCRIPTION
IQ-1 is a selective inhibitor of Beta-catenin/p300 signaling by binding to protein phosphatase 2. It is used to maintain embryonic cell pluripotency in Wnt3a-treated cells and prevent spontaneous differentiation. It is also reported to upregulate the expression of Sox2 and Oct4 transcription factors.
DETAILS
- Purity: ≥98%
- Synonyms: ST50223451, MLS000559249, AC1NY3UK, CHEMBL3193709
- Cas Number: 331001-62-8
- References: cMiyabayashi, T., Teo, J. L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007). Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proceedings of the National Academy of Sciences, 104(13), 5668-5673. Chase, L. G., & Firpo, M. T. (2007). Development of serum-free culture systems for human embryonic stem cells. Current opinion in chemical biology,11(4), 367-372. Miki, T., Yasuda, S. Y., & Kahn, M. (2011). Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Reviews and Reports, 7(4), 836-846.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: (2E)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
- Molecular Weight: 362.4
- Molecular Formula: C21H22N4O2
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N