DSCR5 Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 51227
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PIGP
Other Names: Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC
Availability: 2 weeks
Bio Background: DSCR5 is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. DSCR5 is an N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). The DSCR5 gene is located in the Down Syndrome critical region (DSCR) on chromosome 21 and is a candidate for the pathogenesis of Down syndrome.
Bio References: Choi, D.K., et al., Mamm. Genome 12(5):347-351 (2001).Togashi, T., et al., DNA Res. 7(3):207-212 (2000).Watanabe, R., et al., EMBO J. 19(16):4402-4411 (2000).Shibuya, K., et al., Biochem. Biophys. Res. Commun. 271(3):693-698 (2000).
Primary Accession: P57054
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP6322c was selected from the Center region of human DSCR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.