sc-133222 AF594
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PKLR (E-2) Alexa Fluor® 594
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG2a; PKLR Antibody (E-2) is an IgG2a κ mouse monoclonal PKLR antibody (also designated PKLR antibody) that detects the PKLR protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. PKLR Antibody (E-2) is available as both the non-conjugated anti-PKLR antibody form, as well as multiple conjugated forms of anti-PKLR antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In mammals, four different isoenzymes exist for pyruvate kinase. Based on their tissue distribution, the isoenzymes are designated L-type (for predominant expression in the liver), R-type (for predominant expression in red blood cells), M1-type (for predominant expression in muscle, brain and heart) and M2-type (for predominant expression in fetal tissues). Pyruvate kinases are responsible for catalyzing the final step in glycolysis: the conversion of phosphoenolpyruvate to pyruvate with the coinciding generation of ATP. The PKLR (pyruvate kinase, liver and RBC) gene encodes the L- and R-type isoenzymes through alternative splicing events under the control of different promoters. The R-type isoform, also known as RPK (R-type pyruvate kinase), exists as a tetramer and, when functioning improperly, can result in chronic/hereditary nonspherocytic hemolytic anemia (CNSHA/HNSHA) or pyruvate kinase hyperactivity (also called high red cell ATP syndrome). The L-type isoform, alternatively known as PKL (pyruvate kinase L-type), also exists as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young (MODY).
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: P30613
- Clonality: Monoclonal
- Conjugate: AF594
- Applications: WB(RGB), IF, IHC(P), FCM
- Human Gene Id: 5313
- Mouse Gene Id: 18770
- Protein Target: PKLR
- Human Gene Name: PKLR
- Mouse Gene Name: Pklr
- Species Reactivity: mouse, rat, human
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