mouse monoclonal IgG1; Bcl-11b Antibody (F-4) is an IgG1 κ mouse monoclonal Bcl-11b antibody (also designated BCL11B antibody, CTIP2 antibody, or RIT1 antibody) that detects the Bcl-11b protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Bcl-11b Antibody (F-4) is available as both the non-conjugated anti-Bcl-11b antibody form, as well as multiple conjugated forms of anti-Bcl-11b antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.