27324-MSM1-P0 27324-MSM1-P1 27324-MSM1-P1ABX
TOX3 / TNRC9 - CloneID - TOX3/1123
NeoBiotechnologies
DESCRIPTION
It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
DETAILS
- Host: Mouse
- Gene ID: 27324
- Uniprot: O15405
- Clone ID: TOX3/1123
- Clonality: Monoclonal
- Gene Name: TOX3
- Supplied As: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Applications: WB
- Protein Target: TOX3
- Species Reactivity: Human
- Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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