1493-MSM1-P0 1493-MSM1-P1 1493-MSM1-P1ABX
CTLA4 / CD152 (Negative Regulator of T-Cells) - CloneID - L4P2F5.F10
NeoBiotechnologies
DESCRIPTION
CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
DETAILS
- Host: Mouse
- Gene ID: 1493
- Uniprot: P16410
- Clone ID: L4P2F5.F10
- Clonality: Monoclonal
- Gene Name: CTLA4
- Supplied As: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Applications: FLOW, WB, IF
- Protein Target: CTLA4
- Species Reactivity: Cow, Cat, Mouse , Rat
- Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.