6011964-25mg 6011964-10mg
TWS 119
Biogems
DESCRIPTION
TWS 119 is a potent glycogen synthase kinase-3β inhibitor (IC50 =30nM). It is used to induce neuronal differentiation and functions as a WNT pathway activator. TWS 119 is also reported to promote the expression of CD62L in NK cells and inhibit the proliferation and induce apoptosis of alveolar rhabdomyosarcoma (ARMS) cells.
DETAILS
- Purity: ≥90%
- Synonyms: TWS119; TWS-119; GSK-3beta Inhibitor XII, Neurogenesis Inducer
- Cas Number: 601514-19-6
- References: Zeng, F. Y., Dong, H., Cui, J., Liu, L., & Chen, T. (2010). Glycogen synthase kinase 3 regulates PAX3–FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochemical and biophysical research communications, 391(1), 1049-1055. Doble, B. W., & Woodgett, J. R. (2009). Exploring pluripotency with chemical genetics. Cell Stem Cell, 4(2), 98-100. Ding, S., Wu, T. Y., Brinker, A., Peters, E. C., Hur, W., Gray, N. S., & Schultz, P. G. (2003). Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences, 100(13), 7632-7637.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
- Molecular Weight: 318.3
- Molecular Formula: C18H14N4O2
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O