Human KIR2DL1 / CD158a / NKAT-1 Protein, Fc Tag

DESCRIPTION

Killer cell immunoglobulin-like receptor 2DL1(KIR2DL1), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction of KIR and HLA is implicated in viral infections, autoimmunity, and reproduction and there is growing evidence of the coevolution of these two independently segregating gene families. Association of KIR2DL1 with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling.

DETAILS

Tag: C-Fc
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Format: Powder
Purity: 90%
Source: Human KIR2DL1, Fc Tag (KI1-H5255) is expressed from human 293 cells (HEK293). It contains AA His 22 - Arg 242 (Accession # P43626-1).
Storage: -20℃
Category: Others
Molecule: KIR2DL1
Accession: NP_055033.2
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: His 22 - Arg 242
Swiss-prot: P43626-1
Package Size: 1mg*1
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 50.7 kDa
Shipping Condition: RT
Species Reactivity: Human
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