Verapamil hydrochloride

DESCRIPTION

Verapamil is an L-type calcium channel blocker and an inhibitor of drug efflux pump proteins such as P-glycoprotein that are often over-expressed in certain tumor cell lines. It is reported to exhibit vasodilator effects and increase the supply of blood and oxygen to the heart.

DETAILS

Purity: ≥98%
Synonyms: Verapamil HCl, Manidon, Veroptinstada
Cas Number: 152-11-4
References: Lee, K. S., & Tsien, R. W. (1983). Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature, 302(5911), 790. Henry, P. D. (1980). Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. The American journal of cardiology, 46(6), 1047-1058. Miller, T. P., Grogan, T. M., Dalton, W. S., Spier, C. M., Scheper, R. J., & Salmon, S. E. (1991). P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. Journal of Clinical Oncology, 9(1), 17-24.
Application: FA
Formulation: Crystalline solid
Chemical Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
Molecular Weight: 491.1
Molecular Formula: C27H38N2O4 HCL
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl