E6503Hu
Human Gamma-aminobutyric Acid Receptor Subunit Alpha-1, GABRA1 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725).
Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750).
The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).
The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750).
GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity).
Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
DETAILS
- GeneID: 2554
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 51,802
- Synonyms: DEE19;ECA4;EIEE19;EJM;EJM5;GABA(A receptor subunit alpha-1;GABRA1 ;Gamma-aminobutyric acid receptor subunit alpha-1
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: GABRA1
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.041ng/ml
- Target Protein: GABRA1
- Detection Range: 0.1-35ng/ml
- Full Product Name: Gamma-aminobutyric acid receptor subunit alpha-1
- Standard Solution: 40ng/ml
- UniProt Accession: P14867