33302
Scientist.com Supplier
MTP 131 (acetate)
Cayman Chemical
DESCRIPTION
A mitochondria-targeted peptide antioxidant; reduces tert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells from 0.001 to 1 nM; reduces infarct volume, hemispheric swelling, and GSH depletion in a mouse model of MCAO-induced acute cerebral ischemia at 2 mg/kg; increases survival, improves motor function, and decreases degeneration of the lumbar spinal cord in the SOD1G93A transgenic mouse model of ALS at 5 mg/kg; reduces albuminuria, urinary hydrogen peroxide levels, and mesangial matrix accumulation, as well as preserves superoxide production, in a db/db mouse model of diabetic nephropathy
DETAILS
- Inchi: InChI=1S/C32H49N9O5.C2H4O2/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21;1-2(3)4/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38);1H3,(H,3,4)/t24-,25+,26+,27+;/m1./s1
- Purity: ≥95%
- Raptas: Product Type|Biochemicals|Antioxidants||Product Type|Biochemicals|Peptides||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Amyotrophic Lateral Sclerosis||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
- Smiles: CC(C=C(C=C1C)O)=C1C[C@H](NC([C@H](N)CCCNC(N)=N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O.CC(O)=O
- Inchikey: UEYRJRBULBAAEG-NFWUDPOKSA-N
- Cas Number: 1334953-95-5
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C32H49N9O5 • XC2H4O2
- Formula Weight: 639.8
- Shelf Life Days: 1460
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