Cyclic Pifithrin-Alpha Hydrobromide

DESCRIPTION

Cyclic Pifithrin-alpha is a reversible and cell-permeable inhibitor of p53, which plays a crucial role in apoptosis, angiogenesis, and genomic stability. The cyclic form is the more stable and less cytotoxic version of the molecule. It is reported to be capable of increasing the efficiency of inducing pluripotent stem cells.

DETAILS

Purity: ≥95%
Synonyms: Cyclic Pifithrin-alpha, 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, Pifithrin-beta hydrobromide
Cas Number: 511296-88-1
References: Liao, J., Marumoto, T., Yamaguchi, S., Okano, S., Takeda, N., Sakamoto, C., ... & Tani, K. (2013). Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. Molecular Therapy, 21(6), 1242-1250. Zuco, V., & Zunino, F. (2008). Cyclic pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent–induced apoptosis. Neoplasia, 10(6), 587-596. Pietrancosta, N., Maina, F., Dono, R., Moumen, A., Garino, C., Laras, Y., ... & Kraus, J. L. (2005). Novel cyclized Pifithrin-α p53 inactivators: synthesis and biological studies. Bioorganic & medicinal chemistry letters, 15(6), 1561-1564.
Application: FA
Formulation: Crystalline solid
Chemical Name: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide
Molecular Weight: 349.3
Molecular Formula: C16H16N2S HBr
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br