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39513

CL097

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C13H14N4O/c1-2-18-7-10-16-11-8-5-3-4-6-9(8)15-13(14)12(11)17-10/h3-6H,2,7H2,1H3,(H2,14,15)(H,16,17)
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition
  • Smiles: NC1=NC2=CC=CC=C2C3=C1N=C(COCC)N3
  • Inchikey: DEVCLHVFELRPIU-UHFFFAOYSA-N
  • Cas Number: 1026249-18-2
  • Formulation: A solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C13H14N4O
  • Formula Weight: 242.3
  • Shelf Life Days: 1460

DESCRIPTION

A dual agonist of TLR7 and TLR8; induces activation of NF-κB in HEK293 cells expressing human TLR7 or TLR8 at 0.1 and 1 µg/ml, respectively; induces TNF-α production and enhances LPS- or hyaluronic acid-induced TNF-α, IL-10, and IL-12 production in isolated human monocyte-derived macrophages; increases pancreatic lymph node IFN-α levels in pre-diabetic NOD mice