GMP Human IL-10 Protein

DESCRIPTION

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]

DETAILS

Tag: Native
Host: HEK293
Size: 50ug
Buffer: PBS, pH7.4
Format: Powder-GMP
Purity: 95%
Source: GMP Human IL-10 Protein (GMP-L10H25) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Asn 178 (Accession # P22301).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: IL-10
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 5 years in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Exp Region: Ser 19 - Asn 178
Swiss-prot: P22301.1
Package Size: 50ug*1
Characteristics: This protein carries no "tag". The protein has a calculated MW of 18.6 kDa. The protein migrates as 17 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 10 EU/mg
Molecular Weight: 18.6 kDa
Shipping Condition: Blue ice
Species Reactivity: Human
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