CD8B1 Antibody (C-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 926
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CD8B
Other Names: T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1
Availability: 2 weeks
Bio Background: The CD8 antigen is a cell surface glycoprotein found onmost cytotoxic T lymphocytes that mediates efficient cell-cellinteractions within the immune system. The CD8 antigen, acting as acoreceptor, and the T-cell receptor on the T lymphocyte recognizeantigens displayed by an antigen presenting cell (APC) in thecontext of class I MHC molecules. The functional coreceptor iseither a homodimer composed of two alpha chains, or a heterodimercomposed of one alpha and one beta chain. Both alpha and betachains share significant homology to immunoglobulin variable lightchains. This gene encodes the CD8 beta chain isoforms. Multiplealternatively spliced transcript variants encoding distinctmembrane associated or secreted isoforms have been described. Apseudogene, also located on chromosome 2, has been identified.
Bio References: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chen, M.L., et al. Eur. J. Immunol. 39(12):3423-3435(2009)Thakral, D., et al. J. Immunol. 180(11):7431-7442(2008)Stove, V., et al. J. Virol. 79(17):11422-11433(2005)Moody, A.M., et al. J. Biol. Chem. 278(9):7240-7246(2003)
Primary Accession: P10966