21716
Mycophenolic Acid
Cayman Chemical
DESCRIPTION
An immunosuppressive microbial metabolite; an active metabolite of mycophenolate mofetil; inhibits IMPDH type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays); inhibits DNA synthesis in L strain mouse fibroblasts at 0.1-10 µg/ml; active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 µg/ml), as well as various strains of S. aureus (MICs = 31.25-125 µg/ml); reduces splenomegaly in a mouse model of Friend virus-induced leukemia at 150 mg/kg; decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep RBCs at 60-240 mg/kg
DETAILS
- Inchi: InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Neuroscience|Neuroprotection
- Smiles: O=C1OCC2=C1C(O)=C(C/C=C(C)/CCC(O)=O)C(OC)=C2C
- Inchikey: HPNSFSBZBAHARI-RUDMXATFSA-N
- Cas Number: 24280-93-1
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C17H20O6
- Formula Weight: 320.3
- Shelf Life Days: 1460