Anti-Tyrosinase-Related Protein-1 (TRP-1) (Melanoma Marker) Monoclonal Antibody(Clone: SPM456)

DESCRIPTION

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence sµggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

DETAILS

Gene: TYRP1
App Id: FACS,IF
Gene Id: 7306
Isotype: Mouse IgG2a, kappa
Clone Name: SPM456
Uniprot Id: P17643
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human, Mouse
Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP
Application Note: Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: SK-MEL-23 cells