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E0925Hu

Human Phospholipidase A2, PL-A2 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed: 1420353, PubMed: 10681567, PubMed: 17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed: 1420353, PubMed: 10681567, PubMed: 17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed: 7721806, PubMed: 25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed: 25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

DETAILS

  • GeneID: 5319
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 16,360
  • Synonyms: Group IB phospholipase A2;Phosphatidylcholine 2-acylhydrolase 1B;Phospholipase A2;PLA 2G1B;PLA2G1B
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: PLA2G1B
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.096ng/ml
  • Target Protein: PLA2G1B
  • Detection Range: 0.2-60ng/ml
  • Full Product Name: Phospholipidase A2
  • Standard Solution: 64ng/ml
  • UniProt Accession: P04054