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HY-130665

TL12-186

MedChem Express

- Open Babel Depiction N O N H O N H O NH O O N Cl N H CH 3 S O O NH N H 3 C N N O O

DESCRIPTION

TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM)[1].

DETAILS

  • Purity: >98%
  • Smiles: O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
  • Category: Reference compound
  • Lead Time: 1-2 days
  • Cas Number: 2250025-88-6
  • Molecular Weight: 931.46
  • Molecular Formula: C44H51ClN10O9S

Lead Time: 1 - 2 weeks

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