mouse monoclonal IgM; CysLT2 Receptor Antibody (B-7) is an IgM κ mouse monoclonal CysLT2 Receptor antibody (also designated CysLT2 Receptor antibody) that detects the CysLT2 Receptor protein of mouse, rat and human origin by WB, IP, IF and ELISA. CysLT2 Receptor Antibody (B-7) is available as the non-conjugated anti-CysLT2 Receptor antibody. Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein- coupled receptors, designated CysLT1 and CysLT2 receptors, to induce potent bronchoconstriction. Airway smooth muscle and macrophages express both receptor types, and additionally monocytes and eosinophils express CysLT1 receptor, while cardiac Purkinje cells, adrenal medulla, peripheral blood leukocytes and brain also utilize CysLT2 receptor. The effects of the CysLT receptors can be blocked by antagonists, indicating a therapeutic mechanism for the treatment of asthma and allergies.