36-2950-20 36-2950
Anti-Cytochrome C (Mitochondrial Marker) Monoclonal Antibody(Clone: 6H2.B4)
Abeomics
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DESCRIPTION
Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thoµght to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
DETAILS
- Gene: CYCS
- App Id: FACS,IF
- Gene Id: 54205
- Isotype: Mouse IgG1, kappa
- Clone Name: 6H2.B4
- Uniprot Id: P99999
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Reactivity Id: Human, Mouse, Rat
- Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Alternative Name: CYC; CYCS; HCS; THC4
- Application Note: Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);,
- Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
- Immunogen Information: Rat full-length cytochrome c protein
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