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ALN-H52H8-200ug ALN-H52H8-1mg

Human Alpha-Synuclein Protein, His Tag

ACROBiosystems

DESCRIPTION

Human Alpha-Synuclein, His Tag (ALN-H52H8) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).

DETAILS

  • Tag: C-10×His
  • Host: E. coli
  • Size: 200ug
  • Buffer: 100 mM NaAC, pH7.0
  • Format: Powder
  • Purity: 90%
  • Storage: -20℃
  • Category: Other Recombinant Proteins
  • Molecule: Alpha-Synuclein
  • Accession: NP_000336.1
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
  • Exp Region: Met 1 - Ala 140
  • Swiss-prot: P37840-1
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE).
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 16.3 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html