Human Alpha-Synuclein Protein, His Tag

DESCRIPTION

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

DETAILS

Tag: C-10×His
Host: E. coli
Size: 1mg
Buffer: 100 mM NaAC, pH7.0
Format: Powder
Purity: 90%
Source: Human Alpha-Synuclein, His Tag (ALN-H52H8) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: Alpha-Synuclein
Accession: NP_000336.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 1 - Ala 140
Swiss-prot: P37840-1
Package Size: 1mg*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 16.3 kDa
Shipping Condition: RT
Species Reactivity: Human
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