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T62503

EGFR/BRAFV600E-IN-1

TargetMol

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DETAILS

  • Purity: 98%
  • Smiles: Cc1c2C(=O)N(CCc3ccc(cc3)N3CCOCC3)CC(=O)n2c2ccc(Cl)cc12
  • Category: Compounds
  • Cas Number: 2492429-45-3
  • Molecular Weight: 437.92
  • Molecular Formula: C24H24ClN3O3

DESCRIPTION

EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAF V600E dual inhibitor with IC 50 s of 0.08 and 0.15 μM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC 50 s of 1.2, 0.79, 1.3, and 1.23 μM, respectively [1].

Lead Time: 4 - 5 weeks

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