mouse monoclonal IgG2b; eIF3θ Antibody (E-1) is an IgG2b κ mouse monoclonal eIF3 theta antibody (also designated eIF3θ antibody) that detects the eIF3 theta protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. eIF3θ Antibody (E-1) is available as both the non-conjugated anti-eIF3 theta antibody form, as well as multiple conjugated forms of anti-eIF3 theta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3α, eIF3β, eIF3γ, eIF3δ, eIF3ε, eIF3Ω, eIF3η and eIF3θ, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.